Renal function drives dosing across antibiotics, anticoagulants, oncology medications, and specialty IV therapies. This command-center calculator compares Cockcroft-Gault, CKD-EPI 2021, Jelliffe, and measured GFR side-by-side so pharmacists can see the dosing impact clearly.
Cockcroft-Gault (1976) has been the dosing standard for decades, but it overestimates GFR in modern populations. CKD-EPI 2021 is more accurate — but it has variants: indexed vs. de-indexed, and the 2021 version removed the race coefficient. Different institutions use different formulas, and a single patient's "CrCl" can be 20–40% different depending on which formula you choose.
You can't just pick one. Your pharmacy protocol defines which formula to use for dosing decisions.
The classic formula, still widely used despite known overestimation. Variants use actual, ideal, or adjusted body weight depending on patient BMI.
The current KDIGO standard. Removes the race coefficient and provides better accuracy across populations. De-indexed and indexed variants available.
Alternative formula sometimes used in institutions with specific protocols or patient populations.
Direct input of measured glomerular filtration rate (from iohexol clearance, EDTA scan, or cystatin C). Gold standard when available.